Arrest Chemokines

Arrest Chemokines

In most organs, leukocyte attachment to the endothelium of blood vessels requires capture and rolling before firm adhesion is initiated by integrin activation and/or redistribution, which can be initiated by immobilized chemokines binding their cognate receptors on rolling cells. Such arrest chemokines are present on the endothelial surface under physiologic or pathologic conditions, necessary,...

GRO family chemokines are specialized for monocyte arrest from flow.

Chemokines participate in various processes of monocyte recruitment including monocyte arrest and migration. Our group and others have demonstrated that growth-related oncogene (GRO)-alpha (CXCL1) can support monocyte arrest in models of inflammation. Here we employed a parallel plate-flow chamber and Transwell reconstitution assay to test whether GRO family chemokines were sufficient for Mono ...

Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest

Leukocyte trafficking to acute sites of injury or infection requires spatial and temporal cues that fine tune precise sites of firm adhesion and guide migration to endothelial junctions where they undergo diapedesis to sites of insult. Many detailed studies on the location and gradient of chemokines such as IL-8 and other CXCR ligands reveal that their recognition shortly after selectin-mediate...

Chemokines.

Chemokines.

not been systematically examined. Similar clustering has C been observed among genes encoding chemokine receptors. HEMOKINES have recently become the focus of intense interest and discussion. This has occurred, in One exception to the CC/CXC rule is lymphotactin, a part, because of an enlarging view of what chemokines do. potent attractant for T lymphocytes, but not monocytes. As recently as 2 ...